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Extra virgin olive oil: what the evidence says about the heart
The everyday fat of the Mediterranean diet. A large Spanish trial and many cohort studies favor it over butter and other saturated fats, though like any oil it is calorie-dense.
By the editors of Alimentotherapy Last reviewed 5 min read Not medical advice
Olive oil
Olea europaea
Best-supported use: Heart health, as part of a Mediterranean diet
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The short answer
Extra virgin olive oil has moderate evidence for heart health: in the PREDIMED trial of 7,447 older Spaniards at high cardiovascular risk, a Mediterranean diet with extra virgin olive oil was followed by fewer heart attacks, strokes and cardiovascular deaths than a reduced-fat diet Estruch 2018. FDA calls the evidence for high-oleic oils "supportive but not conclusive", and the benefit depends on olive oil replacing saturated fat, not adding to it FDA.
The evidence, use by use
Each claim graded on human studies only. How we grade
| Use | Grade | What the research found |
|---|---|---|
| Heart attacks and strokes in people at high risk (Mediterranean diet with extra virgin olive oil) | Moderate | In PREDIMED (7,447 adults aged 55 to 80, median follow-up 4.8 years), major cardiovascular events occurred in 3.8% of the olive oil group and 4.4% of the reduced-fat control group (hazard ratio 0.69). The trial was republished in 2018 after randomization problems at some sites; results held in the reanalysis. Estruch 2018 |
| Blood sugar control in type 2 diabetes | Moderate | A meta-analysis including 29 trials found olive oil lowered HbA1c by 0.27 percentage points and fasting glucose by 0.44 mmol/L more than control diets in people with type 2 diabetes. Schwingshackl 2017 |
| Living longer (observational) | Limited | In two US cohorts (92,383 adults followed for 28 years), people having more than half a tablespoon a day had 19% lower all-cause mortality than those who rarely used it. Cohort studies cannot rule out that olive oil users differ in other ways. Guasch 2022; Schwingshackl 2014 |
| Stroke and cardiovascular events (observational) | Limited | Pooling 32 cohort studies (841,211 people), higher olive oil intake was linked with lower risk of cardiovascular events and stroke; monounsaturated fat from mixed animal and plant sources was not. Schwingshackl 2014 |
PREDIMED: the trial behind the advice
PREDIMED is the reason olive oil sits at the top of most heart-diet advice. Researchers in Spain assigned 7,447 people aged 55 to 80, all at high cardiovascular risk but without heart disease, to one of three diets: a Mediterranean diet with free extra virgin olive oil, a Mediterranean diet with free mixed nuts, or a control diet with advice to cut fat Estruch 2018.
After a median of 4.8 years, a heart attack, stroke or cardiovascular death had occurred in 96 people in the olive oil group (3.8%), 83 in the nut group (3.4%) and 109 in the control group (4.4%). Adjusted for baseline differences, the olive oil diet carried a hazard ratio of 0.69 compared with controlEstruch 2018.
The trial has a history worth knowing. The original 2013 report was withdrawn after the investigators found protocol problems: some household members were enrolled without randomization, and one site assigned groups without randomizing at all. The 2018 republication reanalysed the data without assuming everyone was randomized, and the results were similar after leaving out 1,588 participants whose assignment was in doubt Estruch 2018. That is why this page grades the evidence moderate rather than strong: it is one large trial, in one country, testing a whole diet with olive oil rather than olive oil alone.
What FDA allows on the label
FDA does not let food labels make full health claims for olive oil. It allows "qualified" claims, a category for evidence that is promising but not settled. FDA lists a 2004 qualified claim for monounsaturated fat from olive oil and coronary heart disease FDA, and in 2018 it accepted a claim for oils with at least 70% oleic acid, naming olive oil among them FDA.
The approved wording is careful: "supportive but not conclusive scientific evidence suggests that daily consumption of about 1½ tablespoons (20 grams) of oils containing high levels of oleic acid, when replaced for fats and oils higher in saturated fat, may reduce the risk of coronary heart disease." FDA adds that the oil should not increase the total calories you eat in a day FDA.
The swap matters more than the oil
Every piece of evidence here is about replacement. In the US cohort study, swapping 10 grams a day of margarine, butter, mayonnaise or dairy fat for the same amount of olive oil was linked with 8% to 34% lower risk of death from various causes. Compared with other vegetable oils combined, olive oil showed no clear advantage Guasch 2022. The cohort meta-analysis found the same pattern: olive oil was associated with lower risk, while monounsaturated fat from mixed sources, including meat, was notSchwingshackl 2014.
So the practical step is to cook and dress food with olive oil in place of butter and other solid fats, alongside more vegetables, beans, whole grains and nuts. Pouring extra oil on an otherwise unchanged diet adds calories and is not what the trials tested.
Blood sugar
Four cohort studies with 15,784 cases of type 2 diabetes found people with the highest olive oil intake had a 16% lower risk than those with the lowest, though the relationship was not a straight line. In trials in people who already had type 2 diabetes, olive oil lowered HbA1c by 0.27 percentage points more than control diets Schwingshackl 2017. The authors note the finding applies to olive oil as a food, not to any single compound extracted from it. If blood sugar is your concern, see the blood sugar page for other foods with trial evidence.
Choosing and using it
PREDIMED supplied extra virgin olive oil, the grade pressed without heat or solventsEstruch 2018. It keeps more of the olive's natural compounds than refined "light" or "pure" olive oil, though the trials do not show which of those compounds matter.
In the kitchen
Store olive oil in a cool, dark cupboard with the cap on, and buy a bottle you will finish within a few months of opening: light, heat and air turn it stale. Extra virgin oil is fine for everyday sauteing and roasting at home.
A supermarket bottle is all you need. If you want a wider choice of single-origin extra virgin oils, iHerb lists extra virgin olive oils from several producers.
Before you try it: safety and interactions
Who should avoid it or ask first
- You have been told to follow a low-fat or calorie-restricted diet for a medical reason: ask your clinician or dietitian how olive oil fits.
- You are thinking of using olive oil in place of a prescribed cholesterol or blood pressure medicine: the trials tested diets alongside usual care, not instead of it.
Possible side effects
- Calories: like every oil, olive oil is pure fat and calorie-dense, so adding it on top of your usual diet can raise your calorie intake.
- Loose stools if large amounts are taken by the spoonful.
Pregnancy and breastfeeding
Olive oil in ordinary cooking amounts is a normal food in pregnancy and breastfeeding. There is no reason to take it by the spoonful as a supplement. FDA; Estruch 2018
Medicine interactions
We found no well-documented medicine interactions for olive oil at food amounts. That is not proof there are none: tell your pharmacist about any herb or supplement you take.
Check another food or medicine in the interactions list.
Common questions
How much olive oil a day is good for your heart?
FDA's qualified health claim for high-oleic oils, including olive oil, refers to about 1.5 tablespoons (20 grams) a day replacing fats higher in saturated fat, without raising total calories. FDA describes the evidence as supportive but not conclusive.
Is extra virgin olive oil better than regular olive oil?
The PREDIMED trial used extra virgin olive oil, so that is the form with trial evidence. Extra virgin oil keeps more of the olive's natural compounds, but no trial has shown which of them matter or compared grades head to head for heart outcomes.
Did the PREDIMED trial get retracted?
The original 2013 report was withdrawn after protocol problems with randomization at some sites. The investigators republished a reanalysis in the New England Journal of Medicine in 2018, and the lower rate of heart attacks, strokes and cardiovascular deaths with olive oil and with nuts held up.
Sources
Primary research and government sources, each checked on the date this page was reviewed.
- PubMedEstruch R, et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med. 2018. PMID 29897866.
- PubMedSchwingshackl L, et al. Olive oil in the prevention and management of type 2 diabetes mellitus: a systematic review and meta-analysis of cohort studies and intervention trials. Nutr Diabetes. 2017. PMID 28394365.
- PubMedSchwingshackl L, Hoffmann G. Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies. Lipids Health Dis. 2014. PMID 25274026.
- PubMedGuasch-Ferré M, et al. Consumption of Olive Oil and Risk of Total and Cause-Specific Mortality Among U.S. Adults. J Am Coll Cardiol. 2022. PMID 35027106.
- FDAU.S. Food and Drug Administration. FDA Completes Review of Qualified Health Claim Petition for Oleic Acid and the Risk of Coronary Heart Disease. 2018.
- FDAU.S. Food and Drug Administration. Qualified Health Claims: Letters of Enforcement Discretion.
Keep reading
- GoalFood for a healthy heart: blood pressure and cholesterolEating patterns have the strongest heart evidence: DASH for blood pressure, Mediterranean for heart events, and soluble fiber from oats, barley or psyllium for cholesterol.
- RemedyNutsAlmonds, walnuts, pistachios, peanuts and the rest. Trials consistently show a modest fall in LDL cholesterol, and the feared weight gain did not show up.
- RemedyOily fishSalmon, sardines, mackerel and their kin are the main food source of the omega-3s EPA and DHA. The case for eating them is stronger than the case for fish oil capsules.
- GoalFood and blood sugar: fiber, whole grains, cinnamon and vinegarRaising fiber and choosing whole grains have the best evidence for steadier blood sugar. Cinnamon and apple cider vinegar get far more attention than their trials justify.
- ToolFood and drug interactionsCheck a remedy or food against common medicines.