Food and medicine interaction
Potassium-rich foods and potassium salt substitutes and ACE inhibitors (such as lisinopril), ARBs and potassium-sparing diuretics
EstablishedEvidence level: established. Shown in drug labeling or in controlled studies in people.
Last reviewed
What can happen
These medicines reduce how much potassium the kidneys get rid of. Adding potassium supplements or potassium-based salt substitutes can push blood potassium too high, especially with kidney disease.
- Why it happens
- ACE inhibitors, ARBs and potassium-sparing diuretics reduce aldosterone's effect, so the kidneys retain potassium.
- At ordinary food amounts
- Salt substitutes and supplements are the main concern; MedlinePlus advises talking to your doctor before using potassium salt substitutes with lisinopril. Ordinary portions of fruit and vegetables matter mainly if kidney function is reduced.
What to do
Talk to your prescriber before using a salt substitute or potassium supplement. Most people on these drugs do not need to avoid fruit and vegetables; ask whether your kidney function means you should limit potassium.
Never stop or change a prescribed medicine without talking to the prescriber.
Common questions
Can I have potassium-rich foods and potassium salt substitutes while taking ACE inhibitors and potassium-sparing diuretics?
Talk to your prescriber before using a salt substitute or potassium supplement. Most people on these drugs do not need to avoid fruit and vegetables; ask whether your kidney function means you should limit potassium. Salt substitutes and supplements are the main concern; MedlinePlus advises talking to your doctor before using potassium salt substitutes with lisinopril. Ordinary portions of fruit and vegetables matter mainly if kidney function is reduced.