Food and medicine interaction
Magnesium supplements and magnesium antacids and oral bisphosphonates such as alendronate (Fosamax)
EstablishedEvidence level: established. Shown in drug labeling or in controlled studies in people.
Last reviewed
What can happen
Magnesium-rich supplements and medicines, such as milk of magnesia, can reduce how much of an oral bisphosphonate is absorbed, so the bone medicine may work less well.
- Why it happens
- Magnesium in the gut interferes with absorption of the bisphosphonate, so less of the dose gets into the body.
- At ordinary food amounts
- The concern is supplements and antacids. Magnesium-rich foods such as nuts, beans and greens are not singled out, as long as you follow your bisphosphonate's empty-stomach directions.
What to do
NIH's Office of Dietary Supplements says taking magnesium-rich supplements or medicines at least 2 hours before or after an oral bisphosphonate can minimize the problem. Ask your pharmacist to set a schedule that fits your bisphosphonate.
Never stop or change a prescribed medicine without talking to the prescriber.
Common questions
Can I have magnesium supplements and magnesium antacids while taking bisphosphonates?
NIH's Office of Dietary Supplements says taking magnesium-rich supplements or medicines at least 2 hours before or after an oral bisphosphonate can minimize the problem. Ask your pharmacist to set a schedule that fits your bisphosphonate. The concern is supplements and antacids. Magnesium-rich foods such as nuts, beans and greens are not singled out, as long as you follow your bisphosphonate's empty-stomach directions.
Sources
Related
- RemedyMagnesium-rich foods: the full evidence pagePumpkin seeds, nuts, beans, leafy greens and whole grains are the main food sources. Many Americans eat less than the recommended amount, and supplement trials show small effects.
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