Food and medicine interaction
Licorice root (glycyrrhizin) and corticosteroids such as prednisolone and prednisone
ProbableEvidence level: probable. Case reports in people plus a known mechanism, but no controlled studies.
Last reviewed
What can happen
Licorice may raise corticosteroid levels in the blood. In 6 healthy men, oral glycyrrhizin (the main active compound in licorice root) increased prednisolone levels and slowed its clearance, and NCCIH notes that interactions between licorice and corticosteroids have been reported.
- Why it happens
- Glycyrrhizin appears to slow the body's breakdown of prednisolone, so more of the steroid stays in the blood for longer.
- At ordinary food amounts
- The study gave 50 mg of glycyrrhizin four times before the steroid dose. Licorice root supplements, licorice tea and candy made with real licorice extract are the forms to mention.
What to do
Tell your prescriber or pharmacist if you use licorice root, licorice tea or real licorice candy while on a steroid. Never stop a steroid suddenly; ask your prescriber first.
Never stop or change a prescribed medicine without talking to the prescriber.
Common questions
Can I have licorice root (glycyrrhizin) while taking corticosteroids?
Tell your prescriber or pharmacist if you use licorice root, licorice tea or real licorice candy while on a steroid. Never stop a steroid suddenly; ask your prescriber first. The study gave 50 mg of glycyrrhizin four times before the steroid dose. Licorice root supplements, licorice tea and candy made with real licorice extract are the forms to mention.
Sources
Related
- RemedyLicorice root: the full evidence pageA traditional throat and stomach remedy with thin evidence and a well-documented downside: regular licorice can raise blood pressure and drop potassium.
- Interaction · EstablishedBlack licorice and licorice root (glycyrrhizin) and blood pressure medicines and diuretics (water pills)
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